Founded in a hotel in downtown Bismarck by an order of Roman Catholic nuns in 1885, Saint Alexius treated both President Teddy Roosevelt and the son of the Sioux chief Sitting Bull. Since then, the medical center has grown to serve a vast region including central and western North Dakota, northern South Dakota and eastern Montana. It has 2,379 employees, including 100 physicians and mid-level providers. In addition to its 306-bed medical center, St. Alexius owns and operates two hospitals and several primary care clinics in North Dakota and manages a hospital in South Dakota. The medical center is sponsored by the Sisters of St. Benedict of the Annunciation Monastery.
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